USC KECK

UNIVERSITY OF SOUTHERN CALIFORNIA KECK SCHOOL OF MEDICINE

www.usc.edu/keck

Edward Crandall, Ph.D., M.D.

Hasting Professor of Medicine

Director, Will Rogers Institute Pulmonary Research Center

Dr. Crandall’s research team continues to expand its activities in cell biology and physiology of the pulmonary alveolar epithelium. Their studies on basic lung pathobiology have relevance to many applied problems, including:

  • Air Pollution
  • Chronis Obstructive Pulmonary Disease (COPD)
  • Interstitial Pulmonary Fibrosis (IPF)
  • Lung Injury

Dr. Crandall’s laboratory utilizes purified lung cell populations grown under controlled conditions. In particular, the alveolar epithelial cells that line the 300 million air sacs in the adult human lung are the primary cells of interest. Using various experimental models of alveolar epithelium, they have shown that the sodium “pump” in the lung helps save lives by removing water from the air spaces, thereby allowing normal uptake of oxygen and excretion of carbon dioxide, processes necessary for normal life. Among their most important recent findings:

  • Keratinocyte growth factor (KGF) can markedly influence the function and differentiation of alveolar epithelial cells
  • Alveolar epithelial cells exhibit “plasticity” in their differentiation characteristics (i.e., they can go forward and backward as they transdifferentiate)
  • Differentiation of alveolar epithelial cells markedly affects the expression of specific genes in these cells
  • Stem cells may be capable of replacing alveolar epithelial cells during recovery from lung injury
  • Exposure of alveolar epithelial cells to inhaled nanoparticles triggers complex intracellular defense mechanisms which cause low level cellular injury that, over a lifetime of exposure, may lead to chronic lung diseases (e.g., COPD and IPF)

These findings together hold promise for the development of new therapeutic tools with which to prevent and treat lung injury/disease using gene- and/or cell-based approaches.